As a tech rush player, I grab it first turn, buy a factory (same on Earth) pump out a few labs with a Social Focus, then Research Focus once they are built. While this is going on, I am looking for a good planet to specialize for research. I usually find and colonize one around the time Mars starts aching under my taxes.
I then "Upgrade" my factory to an entertainment building (you keep the manufacturing bonus right up until it switches) and flat out purchase all future upgrades (bankrolled by tech whoring). On the next game that gives Mars a yellow square, I am going to scrap it as a research planet at this stage and build a farm, entertainment and economic structures and see how it fares as a tax cow.
(EDIT: I choose custom starting techs, and go with good drives, so all I sacrifice is some early early (first 5 turns) Earth improvements and can still do the interstellar land grab)