I waited until the cursor went goofy on the secondary, (it might be a lag), and opened up task manager. using the performance tab, the only things that seemed to be using CPU in any large amounts were Stardock Multiplicity 3 (32 bit) and Desktop Windows Manager. Moving the mouse was causing them to spike, especially Stardock. After restarting, moving the mouse affects the Desktop Manager, but not Stardock. I also notice that I have 2 instances of Stardock Multiplicity 3 (32 bit), but that is the case on the primary as well.
As a note, this stick had been behaving fine for a number of months in this scenario. The cursor issue is new just started happening on this stick in the last couple of weeks. I have not installed anything on the computer other than microsoft updates, the last of which was 2020-12 on 12/9.