Ideas for more challenge?

Greetings...I'm new to 4x games in general, but after a little messing around to get the hang it, I've played two games on "Intelligent" and crushed the AI (large+5 opponents; huge+9 opponents).

So now I'm ready to try a very challenging game. What are some setups you found particularly challenging yet still fun? I assume bumping AI level up to max. But what about initial dispositions, galaxy setup, special rules, etc.?

Cheers,
Stush
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