I did that, it is OK, but not so comfortable, because at my main monitor's desktop I can move files and folders whereever I want (At middle of monitor or in the right up corner e.t.c.) Unfortunately in any folder and in your app I can not do the same 
Usually, when I had single monitor, I saved all temporary files for work (from google chrome, and all others programs) at desktop, and I sorted it whatever place I want
So, after work I have just clearing all temporary files, what I dont need, and saving whitch I needed in other folders on my main hdd disk.