Sorry to hear you are having trouble.
First, you are going to want to make sure you have MP installed on all the machine you want to use MP with.
For Seamless connections, you are going to want to make sure you can see the monitors of the Primary and Secondary (on the same desk). If the Secondary is in another room \ location, where you cannot see the monitors, you are going to want to use KVM connections.
Next, you would want to make sure that the Secondary computer you are trying to reach is on the side of the Primary:
Example of Secondary monitor(s) on right or Primary monitor(s): http://sd.stardock.com/sean/JingImages/2014-11-18_1531.png
Diagonal placement of a Secondary will not work:
http://sd.stardock.com/sean/jingimages/2014-08-05_0950.png
But above and below is fine.
Here is further information on Seamless connections:
http://help.edgerunner.com/Multiplicity%203/Static/default.htm?kvm.htm
If the PCs are not on the same desk (other rooms \ locations), or they are close but one is headless (no monitor) you are going to want to create a KVM connection.
KVM connections will open a window on the Primary where you can view and interact with the Secondary computer. For more information on creating and using a KVM connection, please refer to the following:
http://help.edgerunner.com/Multiplicity%203/Static/default.htm?kvm.htm