@ goa
From what i've seen of the official demonstration vids, the shot itself isn't particularly large(no WW2 style battleship shots).
Well the phalanx anti-missile system onboard a ship might be able to do it, yet mach 5+ is fast. Phalanx systems aren't exactly "small arms fire"(lol) and would really need enough bang to destroy the aerodynamics of the shot, and considering the high ballistic arc (pretty much attacking from above) any small push to either side would throw off targeting and render the shot potentially harmless. Remember its travelling at mach 5, and small things would be hitting it travelling at slower speeds, yet still would be like mini brick walls having a few mach in speed difference. Also, phalanx systems fire a LOT of rounds per second, and the energy of any impact would be enourmous. Any sailors on the boat would be afraid of some shrapnel, as the round would likely be pulverized into thousands of pieces. If I remember rightly the shrapnel issue would be because of the engagement range of the phalanx guns, something that I don't remember, and wouldn't tell you If I did, lol.
At visual range I don't think you would have a chance in hell of stopping one of these shots(visual is something like 26miles to the edge of the horizon). I don't know what the muzzle velocity is, but its gonna be high, and only 26 miles of wind resistance isn't going to do much to that shot. Fast and mean, and oh so effective. I wonder how deeply you could penetrate into a mountain with one of these things. The shots sure would be cheaper then a tomahawk missile.
The main issue imo, would be tracking a small fast moving target to get the right anti missile weapon on target at the right time.