If you mean a kind of long-term politics sim like Victoria or Crusader Kingdoms and the like, then yeah, I could actually see that working out pretty well. Maybe a later stage of the game taking focus away from constructing cities and exploring, and more focus on diplomacy and global warfare.
But I think it's better to avoid the spore trap and just focus on one stage of gameplay.
Also, dwarf fortress is more a state of mind than a game.
A mind filled with MAGMA and INDUSTRY and BOOZE.