I get random crashes to desktop in every game that I play. Sometimes it is 30 seconds in, other times I can play for an hour before it crashes. As a side note, I am a heavy gamer and play several other games for hours on end without any issues.
Here is my setup:
Vista 64bit
E6600
4G RAM
X-Fi Soundblaster
8800GTX
I am playing the game with full graphics. Everything turned up, at the highest resolution. I am currently re-installing it on my XP partition and will report back whether it works there or not. All drivers are updated, btw.