I discovered quite by accident while using IconPackager, when Windows Explorer restarts, the CursorFX tray icon disappears. CursorFX continues to work properly even though the tray icon is missing. You could use this as a work-around by going to the Task Manager and restarting Windows Explorer to remove the tray icon for CursorFX, however, the next time you reboot your system it will be back.
You could also try turning off the CursorFX tray icon in the Windows 10 Settings>Personalization>Taskbar>Select which icons appear on the taskbar and see if that works.