It is better not to load games from within the game currently.  I have suggested to the devs to have no loading or new games from within the game, but they haven't taken this idea up so far.  If your game is using lots of memory without loading from within the game, then that definitely needs to be addressed.

I don't like this idea.  I think this is a Stardock problem.  How come I don't have load/save game issues with my other games?  Perhaps Stardock should hire the Derek / Jon equivalent of load/save game gurus out there and fix this once and for all.  While they're at it, they can fix the game locking up when your PC goes to sleep.  Other games don't lock up when your PC goes to sleep.