Seriously, this could be Stardock's "breakout" title- I'm hoping SD is going to bet the marketing farm on this.
If GalCiv didn't do that for TBS, this game ain't too likely to do much more! (AKA: they already 'broke out' in TBS games, which are a niche game, alas).
On top of that, we have Sins (RTS/4X hybrid) which sold like crazy, and Demigod which is very much a mainstream game which, done to SD quality, will really breakout.
(Or do you mean breakout in their own right, rather than as a producer, in which case the first sentence at least still applies)