Yeah, right click on your desktop, and Radeon Settings should be at the top. Click that. When it loads, the upper left corner should say "Gaming", click that. If you see Ashes of the Singularity: Escalation, click that; If not, in the top right corner is "Browse", click that, and tell it where the game is. Once you've clicked Ashes of the Singularity: Escalation, on the bottom row of settings is one that says "Crossfire" with a bunch of options. Click it, and set it to "Disabled". That way you can check to see if Crossfire is the problem.
Also note, from that same menu, you can physically force Crossfire to run even in DX11, by selecting "Optimize 1X1" for newer games (Such as Ashes), and "AFR Friendly" for older ones. As a warning though, doing so may cause flickering, visual artifacts, lower framerates and/or missing textures in some games.
