Well, this is very disapointing.
We got quite different answers about local area networking (LAN), where both Dustin or Sigaty said they were still discussing it, however, Pardo knew immediately: "we don't have any plans to support LAN," he said and clarified "we will not support it." The only multiplayer available will be on Battle.net.
On the plus side:
When Browder was asked if famous characters like Nova (from the cancelled StarCraft: Ghost) or Michael Liberty (character from a StarCraft novel) will turn up in single player, he said "there is a chance" with a massive grin. "There is definitely a chance, we'll see."