Night Rider belongs on SciFi, and this season's premiere was actually on SciFi weeks before it got to NBC. It would appeal to SciFi's audience more.
Fringe does bring me back to the X-Files days, but I agree that the episodes are too cookie-cutter. I do appreciate the shorter commercial breaks.
Heroes is losing its way with all of this time travel they're doing. They're walking a fine line and they have to be careful.
Lost rules. Two more seasons to go.
Life is the only cop show I watch, and I enjoy it very much. Detective Crews is such a great character.
Chuck is for the geek in all of us, the hope that we can be or do something totally different.
Terminator is good, especially with the new movies around the corner. But again, time travel can be tricky.
Pushing Daisies is phenomenal, it makes me smile.
Other favorites that Seabass didn't mention:
Eli Stone, just watch it, I'm telling you. Listen to me. 
Boston Legal is in its last season and they are pulling out all the stops. The crap that William Shatner (as Denny Crane) says on that show is priceless.
The Office, 30 Rock, Scrubs, the best comedies on TV. Scrubs will get its last season on ABC this year, used to be on NBC.
Ugly Betty and Desperate Housewives, I'm a girl, what can I say. They are both so over the top and fun.
And let's not forget 24! When it comes back in January, it will have been off the air for 1.5 years, except for a prequel thing they're doing in November. We need our Jack Bauer back!
This is TV junkie MeliBee signing off to go hug her DVR.