I have run into all kinds of problems when running 2 monitors @ 2 different resolutions...on my machine, OD+ ran on the larger monitor, but always docked iteself @ the smaller resolution, which made the dock sit about 300 pixels above the edge of the screen (similiar to your screenshot)...moving the dock to the other monitor docked it to the edge ok, but all the mouseovers, seperators, and active indicators stayed on the other monitor *shrug*. A new monitor allowed me to keep both monitors @ 1280x1024, and problems solved! I don't think games have anything to do with it...
OD+ is hardly the only app I ran into to do this though...Photoshop especially liked to pop up it's dialog boxes offscreen. Very frustrating...I will have to check out virtualtrain's link above...although my problems were solved by changing both to the same resolution.
Just checked out the above link - WOW!! chockful of useful info...thanks virtualtrain!