Hello,
Sorry to hear you are having issues. What changed since that desired layout? Windows update? Desktop Onedrive Sync turn on? New software installed? If you create a new save layout, does it get restore correctly? Also need to know your current Windows 10/11 version and OS Build number. Use Winver.exe to get these numbers.
Details on what get icons get lost? Does it still appear on the desktop instead inside a Fence? If you turn off Fences does these lost icons appear on your desktop?
To turn on or off Fences.

Thank you.
Basj,
Stardock Community Assistant.