Mine is doing the same thing, right after this recent update. All my taskbar items on the second screen become unclickable, i have to alt+tab to get to my open programes now. Others are mentioning chrome, but all my apps are unclickable on the second monitor.

It works for a few moments on restart, or restart windows.exe , But within seconds it will bug out. 

There is a 2.51 beta available now which should address this.

The beta has not fixed it for me totally, the bar is no longer completely frozen until i click a window but takes two clicks, one to focus on the start bar then one to open the window

that has seemed to work even though some of my settings appear to have changed (even after importing backup), minor thing though thank you.

The beta seems to fix this for me. Thank you! 

I did uninstall the old version, restarted Windows 11, re-installed the beta.

Same here, started with 2.5. Have 2 monitors connected via docking with laptop. Sometimes taskbar doesn't work on second monitor. When pressing start 2x times doesn a refresh of something and the taskbar comes alive.

I have 2.51 installed, but this does not fix the issue.

I just did the update this morning and everything seem to be working fine. I will give it a spin and report back if I have any issue.

Thank you support & dev team for solving the issue.

I would recommend changing the graphics to state v2.51 in stead of 2.0 This happens during installation. 

Scot