There appears to be a CPU issue with AMD FX processors and or/ Radeon GPU's at the minute that cause extremely long first turns with many AI and Larger maps. Causes 5-10 minute first turns see post.
Brad's reply from stream on long first turn?
Where as other systems don't seem to be effected by this if using an Intel or A10 CPU. In that post there are others with similar setup that see the same issue. Ticket has been created for the issue.
Otherwise the game appears to run good on my system, I do see a slow down on insane maps with 50+ AI around turn 200 (about 10 hours into a game), however, I think that is not a hardware issue but, something else causing the slowdown as it starts to extend from 20-30 seconds around turn 100 and goes up greatly from there.