Hi bgregor01,
Thanks for posting. If you aren't already doing so, can you try selecting "Use advanced resolution aware grid mode"?

Selecting this grid mode (from the Seamless tab) should allow more flexibility with where your PC displays are positioned and could help with mouse entry/exit points from one PC to the next.
Please let us know if using this mode helps. If other specific settings seem to be contributing factors, some more details about your specific configuration/settings may also be helpful.
Best regards,
Adam McGuinness
Stardock Support Specialist