This might be complex to implement for a fairly 'unnecessary/niche' customization - but monitors tend to be positioned in space apart from each other (the desktop areas are right up against each other, but the monitors themselves have frames and gaps).
Could Deskscapes be instructed to render to the window/desktop of a monitor with an offset region to wallpapers / spanned wallpapers/videos?
I'd like the 'empty real space' between monitors to actually be factored in to the spanned images so that they 'make sense' visually. I know I'd be missing seeing the graphic data inbetween completely, but I feel like for some wallpapers it would really make an immersive feel.
Another thought is allowing independent monitor scaling of the viewport content so when monitors have different resolutions, the wallpapers can be scaled to be relatively correct for resolution ratios - also helping to align content across physical borders. Actually that's probably an easier one than the first idea.
I have been able to fiddle with Nvidia virtual resolutions, and desktop dpi scaling etc. to accomplish similar effects, but those tend to be system wide things - I just want to mess with the wallpaper realm of things. 
Silly suggestion?
If I was to think of a UI to manage this - it would sort of be like a rectangle that spans the entire windows virtual desktop space, and then you draw rectangles on it and number them, and then when you assign a wallpaper, you also draw a rectangle on the wallpaper to specify its clipping region. Then deskscapes would be expected to render the clipped region to the desktop space region number. If the same wallpaper is used in multiple regions, you could get away with a single surface render and blting from that for all the regions that use it.
Oh man, and also maybe like, multiple wallpapers could be layerable then, with transparency and blending options and and...
*starts hyperventilating with frantic stupid ideas*.
Almost sounds like a DesktopX hybrid type thing - it couldn't play videos hey... ?