I've tried reloading this 3 times without significant issues. It's possible there is a memory leak on reloads (when it clears out the settings of the former game it isn't clearing everything), but it would be minor because I'm not seeing much growth.
Once you restart the game I assume you are good? About how many times are you reloading your save before you run into a crash?
The thing is that reloading a save two or three times won't make it crash immediately. What I've noticed is that it seems to crash sooner if you reload a save (doesn't have to be the same save, just a reload), so, you'd have to continue playing for a few hours. Not optimal for dev testing, I know. Maybe try five to ten times, I've had it crash like that while reloading a bunch of times to figure out a bug.
It also seems to favor crashing when double clicking a fleet, maybe related, but I've had those without reloading a save. I also had a crash today that's probably the same as this where I crashed while trying to heal a ship and that one was after doing reloading a save a few times (not the same autosave though)
Also, are you trying it on a fresh save or a game that is well underway and a few hundred turns in? That seems to make a difference.