Using Multiplicity v3.42 KM Build 00080, it was downloaded ~3 days ago off the site here.
The Primary computer/monitor is running Windows 10 Anniversary edition (x64) as of a week ago. The secondary computer/monitor is running Windows 7 Pro x64. Both have updated driver sets and run without issue otherwise. The primary has 3 monitors attached, but the game in question only runs on one of them in native 1920x1080 mode.
I can't determine Uplay version through it's UI, nor does the file have detail properties. But it self-updates, and has been run every day for ~3 weeks. I also have Steam installed on the Primary, and it seems to work fine with that (no disconnects/crashes). Ubisoft's software is a bit more aggressive, so it makes sense.
If you'd like a DXdiag or similar, just let me know.