I think I've found a bug with SoaSE and/or OD+.
Normally, I am running OD+ (latest version) with a zoomer dock on the left and tabbed docks at the top and right. I start Sins from the tabbed dock at the top. I've been running this way with no problems since I got OD+ a few months ago.
I hadn't played Sins since the beginning of April due to RL. Tonight, I fired up Sins v1.16 (I don't have Entrenchment) and noticed the following problem. The mouse pointer is not accurate. For example, on the options screen, if I position the cursor arrow in the middle of a push button and click, the button ABOVE the one I clicked on is selected/deselected. However, this only happens when I'm running OD+ (latest version). If I shutdown OD+ before running Sins, the mouse is correct/accurate. This is a recent occurence (since I don't remember it happening when I last played about a month ago). Since OD+ hasn't been updated in a while, perhaps this is a bug with a recent patch to Sins?