There's a glitch with the Taskbar centering properly when there are two monitors. 
My operating system is Windows 10 Home on a Dell Inspiron 17" 7333 2-in-1 2020 laptop. I use the central alignment feature and have an extra *slightly larger 21" monitor I use as my main default monitor. 
The taskbar seems to have a problem going back to its central alignment position everytime I turn on my PC. Sometimes the right side monitor (17" laptop) aligns everything to the left corner, while the larger monitor (an old 21" Fuji-Siemens) seems correctly centered yet a little to the right, as if it was measuring its position off the right side edge a 17" monitor. Other times the problem is reversed; the laptop shows everything properly centered while the right side larger monitor is left side aligned. The problem remains as such unless I open Stardock app, or Taskbar Settings, after which it corrects itself. 
Additionally the Taskbar has trouble widening away from the edge of the screen, like when you try to make your Taskbar fatter. The taskbar apps will remain in place with the start button and search icon along with the task icons and clock on the other end will all move with the widening of the taskbar. I use my taskbar on top, but the same thing happens if I put it on the bottom. Interestingly it doesn't seem to have quite as much trouble if I put the task bar on the left side of the monitor. I've tried different things, like locking or hiding the Taskbar, and it doesn't seem to help.