To set 1 core for sins only (Game should be running).
1. pres control+alt+delete. This should open task manager.
2. Go to applications and right click on SINS. New menu will open.
3. Select go to processes. Now right click on highlighted process (process name should be Sins of solar empire or something similar
4. select Set Affinity. Here you can select cores of your CPU on which process is allowed to execute on
5. make it so that only 1 or 2 cores are ticked (try 1 first if no changes allow 2 cores) Some threads suggest that sins use 1.5 cores. Press OK.
6. right click on highlighted process again and select Set Priority
7. now select Real-time.
8. Go back in the game.
If you try this I hope it works.
WARNING: If you set priority before affinity windows might freeze and be really non responsive. Eventually windows will do what you order them to do but only after game does what it has to do. Game has higher priority than OS.
You might experience slower OS but only when SINS is running. I'm not sure if you need to set cores and affinity every time you run program or settings stays set.
OS should be able to adapt and use 2 or 3 cores that are not used by the game.
EDIT:
Here is link to thread I was talking about in reply 4. Reply 19 is Thomusins post.