Massive battles in the
late-game will bring even most "gaming-rigs" to slideshow-like-presentation state.
1. Keep reducing your graphics settings until it doesn't lag (that much) anymore.
-or-
2. Don't zoom-in during large battles in the late-game
-or-
3. Don't play with so many AI players.
Those are pretty much your options....

Of course, as Kitkun already suggested....make sure you're up-to-date.