I used the search feature and was unable to find any most that matched my problem (I found one that was close though)
I have a Vista and when I play the game I get a Runtime error, I got the hotfix and everything I could think of but it stills crashes ingame.  I can play a game for 2 or 3 hours before it crashes and after that I can only play for about 2 minutes.  The game doesn't lag, the FPS doesn't drop, with no sign that the computer is having problems.  My specs are:

Windows Vista
3GB of RAM
8600 Nvidia Graphics card
2.3GHz Quad core processor

thanks for any help.