100% factories I understand, but--100% labs?
It actually can work better than all factories, depending on your map settings. I wrote an AAR where I illustrate using this method, and in the notes following I went through the math of all labs and all factories vs. using a mix. You actually get the most production per tile for your entire empire using all labs, although all factories is a little more versatile.
I prefer the all labs approach myself, but it is harder to use, which is one reason I have an affinity for it.
See
WWW Link Wow, that's a great AAR. Learned quite a bit from it.
For the highest scoring Suicidal Gigantic all abundant/very fast tech rate games that I don't have the patience for (don't intend to ever play any maps larger than Medium, heh), I think that x/y/0 completely outclasses 0/0/100 since you can colonize so many planets that even a "25%" research rate is huge (especially with very fast tech rate), and being able to build Constructors and Stock Markets at roughly triple the speed is a big deal as well.
But for more average settings, I can believe your claim that the two approaches are roughly evenly matched. And all other things being equal, doing more with a manageable quantity of very high quality resources is more enjoyable for me than just brute-forcing my way to victory. (Though I will note that I just finished an x/y/0 game and found that Psyonic Beams are almost as good as weapons requiring ten times the research; they weren't fully outclassed until I had gotten to Positronic Torp II, long after the game was effectively over.)
Truth be told, I think the DA focus mechanism, from a game balance perspective, makes absolutely no sense and should be fixed if Brad cares to maintain the integrity of his economic model. But it's an interesting kind of broken, especially when you try to engineer swapping from one extreme to the other within a single game. I'll miss it when it's gone.