I had a game that I was going good on and then I had a CTD, when I loaded the last quick save it was fine until I hit next turn and then I get a CTD. This happens no matter what I did, restarting the computer, restarting the game, changing graphical settings.
So I was messing around before I hit end turn to see what kinds of things I could move around to maybe change the saved game data so it would not be corrupt (which was what I was thinking was wrong). It turns out my survey ship that was teleported far away out of range and then was auto-piloting back into range was the culprit. Clicking on that ship and telling it to move causes an immediate CTD. Hitting next turn (and then having the game move the ship) causes a CTD.
My solution was to destroy the ship and the game works fine. There must be a bug involving movement out of range. I have the save file if Stardock is interested in debugging this. I am not sure if it is already accounted for.